EFFECT OF DESMOPRESSIN (DDAVP) ON PROTEIN-C AND PROTEIN-C INHIBITORS IN UREMIA

Authors
AKPOLAT T OZDEMIR O ARIK N DEMIRKAN F SUNGUR C OZCEBE O DUNDAR S YASAVUL U TURGAN C KIRAZLI S CAGLAR S
Citation
T. Akpolat et al., EFFECT OF DESMOPRESSIN (DDAVP) ON PROTEIN-C AND PROTEIN-C INHIBITORS IN UREMIA, Nephron, 64(2), 1993, pp. 232-234
Citations number
11
Categorie Soggetti
Urology & Nephrology
Journal title
Nephron → ACNP
ISSN journal
00282766
Volume
64
Issue
2
Year of publication
1993
Pages
232 - 234
Database
ISI
SICI code
0028-2766(1993)64:2<232:EOD(OP>2.0.ZU;2-K
Abstract
The effect of desmopressin (DDAVP) on protein C (PC) and PC inhibitors was investigated in 7 uremic predialysis patients, 7 hemodialysis pat ients and 7 controls. Significant decrease in PC activity was observed in all groups after DDAVP administration. Desmopressin did not influe nce PC antigen and two well-known PC inhibitors, plasminogen activator inhibitor-3 and alpha1-antitrypsin. Thus, it is suggested that DDAVP- induced decrease in PC activity is not related to the changes in PC in hibitors; further studies are needed to clarify the precise mechanisms of the effect of DDAVP on PC in uremia.