Mj. Filteau et al., REDUCTION IN SUICIDAL IDEATION WITH SSRIS - A REVIEW OF 459 DEPRESSED-PATIENTS, Journal of psychiatry & neuroscience, 18(3), 1993, pp. 114-119
This paper is a review of 459 outpatients treated in double-blind clin
ical drug trials using similar protocols which compared the clinical r
esponses to specific serotonin reuptake inhibitors, norepinephrine reu
ptake inhibitors, mixed norepinephrine serotonin reuptake inhibitors,
serotonin-2 antagonists and placebo. Although improvements in the tota
l score on the Hamilton Rating Scale for Depression did not differ sig
nificantly among the groups, there were differences in the profile of
response based on analysis of the items of the scale. The most strikin
g difference was the significantly more rapid and effective improvemen
t in depressed mood and the lessening of suicidal ideation among the p
atients treated with specific serotonin reuptake inhibitors.