LYMPHOCYTE SUBSETS AND SERUM IMMUNOGLOBULINS IN PATIENTS WITH PREMATURE OVARIAN FAILURE BEFORE AND AFTER ESTROGEN REPLACEMENT

Citation
Pc. Ho et al., LYMPHOCYTE SUBSETS AND SERUM IMMUNOGLOBULINS IN PATIENTS WITH PREMATURE OVARIAN FAILURE BEFORE AND AFTER ESTROGEN REPLACEMENT, Human reproduction, 8(5), 1993, pp. 714-716
Citations number
14
Categorie Soggetti
Reproductive Biology
Journal title
ISSN journal
02681161
Volume
8
Issue
5
Year of publication
1993
Pages
714 - 716
Database
ISI
SICI code
0268-1161(1993)8:5<714:LSASII>2.0.ZU;2-J
Abstract
We have previously demonstrated that in patients with oestrogen defici ency, there was a significant reduction in the ratio of CD4+ to CD8+ l ymphocytes. To test our hypothesis that oestrogen deficiency was the c ause of the changes in lymphocyte subsets, we have studied the lymphoc yte subsets and serum immunoglobulin levels in 35 patients with idiopa thic premature ovarian failure before and after oestrogen replacement therapy. Before oestrogen replacement the lymphocyte subsets in periph eral blood were enumerated with indirect immunofluorescence techniques using monoclonal antibodies. The serum immunoglobulins (Ig) G, A and M were measured with nephelometry. After oestrogen replacement therapy , the tests were repeated around day 7-11 of the 2nd, 4th and 24th mon th. There was no significant change in any of these parameters by the 2nd or 4th months. After 2 years of oestrogen replacement, there was a significant decrease in the percentage of CD8+ cells, a significant i ncrease in the CD4:CD8 ratio and a significant increase in the mean se rum IgG concentration. There was no significant change in the other pa rameters. Our results support the hypothesis that oestrogen deficiency is the cause for the changes in the lymphocyte subsets.