S. Kurusu et al., CIRCADIAN-RHYTHM IN THE QUAIL ELECTRORETINOGRAM (ERG) - POSSIBLE RELATION TO RETINAL INDOLEAMINES (SEROTONIN AND MELATONIN) ACTIVITY, Journal of interdisciplinary cycle research, 24(2), 1993, pp. 141-149
Citations number
23
Categorie Soggetti
Medicine, Research & Experimental","Multidisciplinary Sciences
The effects of intravitreal injections of indoleamines or their inhibi
tors on the quail ERG were investigated. The ratio of b- to a-wave in
amplitudes showed daily fluctuations in the control eyes. Repeated inj
ections of para-chlorophenylalanine (PCPA), an indoleamines synthesis
inhibitor, reduced the ratio to the nocturnal levels. And the level wa
s restored by serotonin injection during the daytime but not during th
e night. Melatonin application into the diurnal eye slightly but signi
ficantly reduced the ratio. Furthermore, 5,7-dihydroxytryptamine (5,7D
HT) which destroyed the indoleamine-accumulating amacrine cells had a
similar effect. These results suggest that the activity of the retinal
indoleamines serotonin and melatonin may be involved in circadian cha
nges of the quail ERG.