KINETIC RESOLUTION OF SECONDARY ALCOHOLS MEDIATED BY RABBIT GASTRIC LIPASE

Authors
LEGROS JY TOFFANO M DRAYTON SK RIVARD M FIAUD JC
Citation
Jy. Legros et al., KINETIC RESOLUTION OF SECONDARY ALCOHOLS MEDIATED BY RABBIT GASTRIC LIPASE, Tetrahedron letters, 38(11), 1997, pp. 1915-1918
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
11
Year of publication
1997
Pages
1915 - 1918
Database
ISI
SICI code
0040-4039(1997)38:11<1915:KROSAM>2.0.ZU;2-F
Abstract
Secondary benzylic alcohols were kinetically resolved by rabbit gastri c lipase-mediated acylation with isopropenyl acetate. Among all the su bstrates tested, a high enantioselectivity was observed only for l-[2- (6-methoxy)naphthyl]ethanol 3a (E>500). Allylic alcohols 14a and 15a w ere also efficiently, resolved (E = 26 and 51 respectively). (C) 1997 Elsevier Science Ltd.