DOPAMINE D1 RECEPTORS IN PARKINSONS-DISEASE AND STRIATONIGRAL DEGENERATION - A POSITRON EMISSION TOMOGRAPHY STUDY

Authors
SHINOTOH H INOUE O HIRAYAMA K AOTSUKA A ASAHINA M SUHARA T YAMAZAKI T TATENO Y
Citation
H. Shinotoh et al., DOPAMINE D1 RECEPTORS IN PARKINSONS-DISEASE AND STRIATONIGRAL DEGENERATION - A POSITRON EMISSION TOMOGRAPHY STUDY, Journal of Neurology, Neurosurgery and Psychiatry, 56(5), 1993, pp. 467-472
Citations number
37
Categorie Soggetti
Psychiatry,Neurosciences,"Clinical Neurology
Journal title
Journal of Neurology, Neurosurgery and Psychiatry → ACNP
ISSN journal
00223050
Volume
56
Issue
5
Year of publication
1993
Pages
467 - 472
Database
ISI
SICI code
0022-3050(1993)56:5<467:DDRIPA>2.0.ZU;2-3
Abstract
Striatal dopamine DI receptors were investigated in 11 patients with P arkinson's disease (PD), five patients with striatonigral degeneration (SND) and six age-matched controls by positron emission tomography an d carbon-11 labelled SCH23390. The SND patients showed mean 12%, 21%, and 31% declines in the ratios of radioactivity in the caudate, anteri or putamen, and posterior putamen compared with that in the occipital cortex. These ratios were not significantly altered in the PD patients . The results may explain the different therapeutic responses to levad opa between SND and PD patients, and this technique might prove useful for their differentiation.