THE USE OF BOTULINUM TOXIN IN THE TREATMENT OF ADDUCTOR SPASMODIC DYSPHONIA

Authors
WHURR R LORCH M FONTANA H BROOKES G LEES A MARSDEN CD
Citation
R. Whurr et al., THE USE OF BOTULINUM TOXIN IN THE TREATMENT OF ADDUCTOR SPASMODIC DYSPHONIA, Journal of Neurology, Neurosurgery and Psychiatry, 56(5), 1993, pp. 526-530
Citations number
26
Categorie Soggetti
Psychiatry,Neurosciences,"Clinical Neurology
Journal title
Journal of Neurology, Neurosurgery and Psychiatry → ACNP
ISSN journal
00223050
Volume
56
Issue
5
Year of publication
1993
Pages
526 - 530
Database
ISI
SICI code
0022-3050(1993)56:5<526:TUOBTI>2.0.ZU;2-I
Abstract
Botulinum toxin injections have been used to treat 31 patients with ad ductor spasmodic dysphonia. Injections of 3.00-3.75 units of botulinum toxin were performed bilaterally into the thyroarytenoid muscle. This treatment significantly decreased the standard deviation of the funda mental frequency of the speech sample, indicating a reduction in the v ariability of pitch amongst patients. A total of 96% of patients' subj ective diary reports showed an improvement with a median of 7 days to peak effect and a 5 week duration of peak effect.