Three new diterpenoids, thuridillins A-C (1-3), have been isolated fro
m the marine mollusk Thuridilla hopei. All metabolites are characteriz
ed by an unusual alpha,beta-epoxy-delta-lactone partial structure. The
origin from an unidentified alga and an ecological role linked to the
defence of the aconchoid ascoglossan are suggested for thuridillins o
n the basis of their structural features.