INVIVO ACCUMULATION OF SODIUM-PUMP INHIBITOR BY NORMAL AND UREMIC ERYTHROCYTES

Authors
GALLICE P LAI E BRUNET P BERLAND Y ELSEN R CREVAT A
Citation
P. Gallice et al., INVIVO ACCUMULATION OF SODIUM-PUMP INHIBITOR BY NORMAL AND UREMIC ERYTHROCYTES, International journal of artificial organs, 16(3), 1993, pp. 120-122
Citations number
7
Categorie Soggetti
Engineering, Biomedical
Journal title
International journal of artificial organs → ACNP
ISSN journal
03913988
Volume
16
Issue
3
Year of publication
1993
Pages
120 - 122
Database
ISI
SICI code
0391-3988(1993)16:3<120:IAOSIB>2.0.ZU;2-I
Abstract
A uremic toxin fraction (fraction 2-3-1) in the middle molecular mass range (300-2000 Da) containing a sodium potassium inhibitor pump was s tudied. As fraction 2-3-1 was known to be present in minute quantities in urine and plasma, erythrocyte lysates were used as an alternative source. Results show that fraction 2-3-1 is more abundant in erythrocy tes than in normal urine. In addition, the fraction is present in a gr eater quantity in uremic erythrocytes than in normal blood cells. It i s concluded that fraction 2-3-1 is concentrated at the erythrocyte lev el in uremic patients.