The cariostatic efficacy of rinsing with a 0.05-0.2% neutral sodium fl
uoride solution has been clearly demonstrated, especially in supervise
d school-based programmes in moderate and high caries risk children. T
he cost-benefit effect, however, is questionable in populations with l
ow caries prevalence, and fluoride rinsing programmes are gradually be
ing replaced by more individual fluoride therapy comprising combinatio
ns of fluoride toothpastes, tablets, or varnishes. Fluoride varnishes
were developed as individual alternatives to conventional topical fluo
ride application and are today gaining acceptance for clinical applica
tion. Two varnishes, Duraphat(R) containing 5%wt NaF and Fluor Protect
or(R) with 0.9% wt fluor silane, are available commercially. The clini
cal effects seem to depend mainly on application frequency, especially
in high caries risk groups. The cost-benefit effect is high, but can
be increased by delegating application to auxiliary personnel in conju
nction with regular dental visits. Toxicologically both fluoride mouth
rinses and fluoride varnishes are safe if used as directed.