Y. Han et al., STOPPED-FLOW EPICARDIAL LYMPH PRESSURE IS AFFECTED BY LEFT-VENTRICULAR PRESSURE IN ANESTHETIZED GOATS, The American journal of physiology, 264(5), 1993, pp. 1624-1628
We measured epicardial lymph pressure (P(lymph)) in the anesthetized g
oat (n = 5 goats). To study the transmission of systolic left ventricu
lar pressure (P(LV)) to P(lymph), the effect of an increase in P(LV) c
aused by clamping of the descending aorta on P(lymph) was evaluated. P
eak systolic P(LV) was 131 +/- 4 (+/- SE) mmHg during control (43 beat
s) and 188 +/- 4 mmHg when elevated due to aortic clamping (157 beats)
. Peak systolic P(lymph) was 24.8 +/- 1.0 and 34.8 +/- 1.1 mmHg during
control and elevated P(LV), respectively. In the first beat of elevat
ed P(LV), peak P(lymph) did not change, although the pressure waveform
did. In the subsequent beats, P(lymph) increased proportionally with
increased P(LV). When P(LV) was decreased back to control, P(lymph) al
so decreased but did not reach control level until after three beats.
The relationship between normalized P(lymph) and normalized P(LV) is g
iven by P(lymph) = 0.70 . P(LV) + 0.09. The results show that P(LV) do
es affect P(lymph) in a normal beating heart.