G. Jahreis et al., INFLUENCE OF SALINOMYCIN AND AVOPARCIN ON THE PLASMA-CONCENTRATION OFINSULIN-LIKE GROWTH-FACTOR OF BEEF-CATTLE, Monatshefte fur Veterinarmedizin, 48(4), 1993, pp. 203-209
The influence of antibiotics on IGF-I concentration was measured in th
ree feeding experiments within beef cattle. Salinomycin and avoparcin
increased significantly the plasma concentration of IGF-I in consequen
ce of improved nutrient supply for animals. The IGF-I level was closer
correlated with the body weight than with the daily weight gain of bu
lls. IGF-I increased significantly in heavier animals. Enhanced produc
tion of sexual steroids of older bulls may stimulate the growth hormon
e release. There existed significant differences between various breed
s in IGF-I concentration, probably caused by a genetic fixed GH-secret
ion. The diet depending IGF-I production in the peripheral tissues (es
p. liver) represents a link between growth hormone axis (genetic possi
ble growth) and the realizable growth depending on nutrient supply.