SODIUM-SALICYLATE EXHIBITS DIVERSE EFFECTS ON THE ACTIVITY OF TETRACYCLINES AGAINST GRAM-NEGATIVE BACTERIA

Authors
DOMENICO P MEHROTRA N QADRI S CUNHA BA
Citation
P. Domenico et al., SODIUM-SALICYLATE EXHIBITS DIVERSE EFFECTS ON THE ACTIVITY OF TETRACYCLINES AGAINST GRAM-NEGATIVE BACTERIA, Medical microbiology letters, 2(3), 1993, pp. 138-144
Citations number
NO
Categorie Soggetti
Microbiology
Journal title
Medical microbiology letters → ACNP
ISSN journal
10184627
Volume
2
Issue
3
Year of publication
1993
Pages
138 - 144
Database
ISI
SICI code
1018-4627(1993)2:3<138:SEDEOT>2.0.ZU;2-3
Abstract
Salicylate interferes with the activity of most antibiotics, particula rly the tetracyclines, against gram-negative bacteria. The degree of a ntagonism is based on several criteria, including the salicylate dose, the class of tetracycline, and the mechanism of tetracycline resistan ce found among bacteria. High-dose salicylate shows only marginal effe cts on efflux-mediated, tetracycline-resistant bacteria, since two pot ent salicylate effects tend to cancel each other out.