INTRAARTERIAL CHEMOTHERAPY OF BREAST-CANCER

Forty-two patients with locally advanced breast cancer (n = 8) or recu rrent breast cancer (n = 34) received regional chemotherapy (mitoxantr one 25 mg/m2 per 24 h) via the internal mammary artery or other vessel s of the subclavian artery. To prevent artery thrombosis 500-1000 U he parin per hour were administered i. v. Tumour perfusion was monitored by intra-arterial angio-CT. Remission rates (CR + PR) were 100% (prima ry breast cancer) and 89% (recurrent tumours), respectively. Intra-art erial chemotherapy was well tolerated. No complications were noted.