AIDA (2) - A MK-II AUTOMATED INSULIN DOSAGE ADVISER

A prototype computer system has been developed to provide advice on th e day-to-day adjustment of insulin dosage in the insulin-dependent (ty pe 1) diabetic patient. The system also allows the patient's daily ste ady-state blood glucose profile to be generated based on these adjustm ents using a clinical model of glucose-insulin interaction. The protot ype is intended to be used as a decision support system by clinical pe rsonnel It is designed for use during consultations, as a simulator of patient response following changes in the insulin and/or dietary regi men, and as a system to provide education on planning insulin therapy. Advice is generated by a qualitative therapeutic advisor which sugges ts what the next step in improving glycaemic control might be for a gi ven patient. The clinical model attempts to reflect the underlying (pa tho)physiology of insulin action and carbohydrate absorption in quanti tative terms. It consists of a one-compartment glucose model linked to a model with plasma and 'active' insulin compartments. An overview of the integrated prototype is provided along with a detailed descriptio n of the new time-point-orientated logical reasoning methodology adopt ed by the therapeutic advisor. The operation of the system is illustra ted by a clinical case study from a 70 kg, male, insulin-dependent dia betic patient.