MEAN RESIDENCE TIME IN MULTICOMPARTMENTAL MODELS WITH TIME DELAYS

Authors
PLUSQUELLEC Y HOUIN G
Citation
Y. Plusquellec et G. Houin, MEAN RESIDENCE TIME IN MULTICOMPARTMENTAL MODELS WITH TIME DELAYS, Journal of biomedical engineering, 15(3), 1993, pp. 240-246
Citations number
22
Categorie Soggetti
Engineering, Biomedical
Journal title
Journal of biomedical engineering → ACNP
ISSN journal
01415425
Volume
15
Issue
3
Year of publication
1993
Pages
240 - 246
Database
ISI
SICI code
0141-5425(1993)15:3<240:MRTIMM>2.0.ZU;2-D
Abstract
Calculation of the mean residence time (MRT) of a drug in a stationary compartmental model is classically carried out from several expressio ns. Nevertheless, one or more time delays between compartments modify the mean residence times. It is the aim of this paper to propose a gen eral method for MRT calculations, in any n-compartmental models which may include time delays. As examples, catenary and mammillary models a re considered.