T. Aoyagi et al., ENZYMATIC CHANGES IN CEREBROSPINAL-FLUID OF PATIENTS WITH ALZHEIMER-TYPE DEMENTIA, Journal of clinical biochemistry and nutrition, 14(2), 1993, pp. 133-139
Previously, we reported protease changes in cerebral tissues, as well
as in serum, of patients with Alzheimer-type dementia. In the present
study, we investigated enzymatic activities in their cerebrospinal flu
id. In the Alzheimer patients the activities of dipeptidyl peptidase I
II (DPP-III), DPP-IV, and cathepsin B were significantly increased whe
n compared with those of the control subjects. In vascular dementia pa
tients the activities of Leu-AP and cathepsin B were increased but the
activity of DPP-III was decreased. These results, as well as those of
a multivariate study on these enzymatic changes, suggest the independ
ency of the cerebral changes in the Alzheimer patients from those in v
ascular dementia. The results may also be of use for clinical diagnose
s of these pathologic states.