STUDIES ON THE INTERACTION OF GOLD(I) THIOMALATE (MYOCHRYSINE) WITH 2-THIOURACIL IN AQUEOUS-SOLUTION FOLLOWED BY C-13 NMR-SPECTROSCOPY

The interaction of gold(I) thiomalate (Autm) ('Myochrysine') with 2-th iouracil (2-TUH) has been studied in aqueous solution by C-13 NMR spec troscopy. 2-TUH is in slow exchange at a 1:1 ratio of Autm:2-TU, but a t higher ratios, fast exchange occurs with the tm- of Autm. No free tm - C-13 NMR resonances were observed. When L-cysteine and CN- were adde d sequentially to the 1:3 ratio of Autm:2-TU solution, the cysteine di d not remove 2-TUH from the complexed 2-TU-Autm, however, CN- bound st rongly to Au(I) forming Au(CN)2-and released 2-TUH and tm- as free lig ands.