TRANSFORMING GROWTH-FACTOR-BETA ISOFORMS EXPRESSIONS IN PULMONARY ADENOCARCINOMAS AS PROGNOSTIC MARKERS - AN IMMUNOHISTOLOGICAL STUDY OF 120 PATIENTS

Authors
TAKANAMI I TANAKA F HASHIZUME T KIKUCHI K YAMAMOTO Y YAMAMOTO T KODAIRA S
Citation
I. Takanami et al., TRANSFORMING GROWTH-FACTOR-BETA ISOFORMS EXPRESSIONS IN PULMONARY ADENOCARCINOMAS AS PROGNOSTIC MARKERS - AN IMMUNOHISTOLOGICAL STUDY OF 120 PATIENTS, Oncology, 54(2), 1997, pp. 122-128
Citations number
21
Categorie Soggetti
Oncology
Journal title
Oncology → ACNP
ISSN journal
00302414
Volume
54
Issue
2
Year of publication
1997
Pages
122 - 128
Database
ISI
SICI code
0030-2414(1997)54:2<122:TGIEIP>2.0.ZU;2-N
Abstract
The transforming growth factor (TGF)-beta 1, TGF-beta 2 and TGF-beta 3 expressions were immunohistologically studied in tissues specimens fr om 120 patients with a pulmonary adenocarcinoma. The results of a univ ariate analysis indicated that the expression of each of the TGF-beta isoforms correlated with the prognosis. Of the three prognostic factor s examined using Cox's stepwise regression model, the TGF-beta 1 isofo rm was found to correlate with survival. These findings suggest that T GF-beta isoforms play an important role in tumor progression and that the TGF-beta 1 isoform is a useful prognostic marker for pulmonary ade nocarcinomas.