IN-VITRO EFFECTS OF RECOMBINANT HUMAN MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR ON PRIMARY HUMAN TUMOR COLONY GROWTH

Authors
LANG SH WEST CML JONES L BROOKS B KASPER C DEWYNTER E TESTA NG
Citation
Sh. Lang et al., IN-VITRO EFFECTS OF RECOMBINANT HUMAN MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR ON PRIMARY HUMAN TUMOR COLONY GROWTH, Oncology, 54(2), 1997, pp. 141-145
Citations number
19
Categorie Soggetti
Oncology
Journal title
Oncology → ACNP
ISSN journal
00302414
Volume
54
Issue
2
Year of publication
1997
Pages
141 - 145
Database
ISI
SICI code
0030-2414(1997)54:2<141:IEORHM>2.0.ZU;2-0
Abstract
A study was made of the in vitro effects of recombinant human megakary ocyte growth and development factor (PEG-rHuMGDF) on breast, prostate, cervix and colon cancers. Tumour growth was assessed using a soft aga r clonogenic assay. Stimulation of megakaryocyte numbers was seen in L iquid culture following 10 ng/ml PEG-rHuMGDF. The same concentration l ed to no significant difference in colony-forming efficiencies for 22 of 25 tumour samples. A significant reduction in colony-forming effici encies was seen for the remaining 3 specimens. These results suggest t hat PEG-rHuMGDF will not stimulate tumour growth in vivo.