L. Kanerva et Km. Niemi, MITOTIC LANGERHANS CELL AS A POSSIBLE SIGN OF ACTIVATION IN ICHTHYOSIS, Journal of cutaneous pathology, 20(2), 1993, pp. 187-189
The fine structure of Lagerhans cells (LC) in four rare types of ichth
yosis, namely recessive ichthyosis congenita type II, III and IV and i
chthyosis hystrix Curth-Macklin was examined. Signs of LC activation w
ere observed in eight of 21 patients. In IC type IV, the rare occurren
ce of a mitotic LC was observed. It is possible that LCs are secondari
ly activated in keratinization disorders.