ANTIFERTILITY EFFECTS IN FEMALE RATS IMMUNIZED WITH HUMAN SEMINAL PLASMA INHIBIN

Authors
HURKADLI KS VERNEKAR VJ SHETH AR
Citation
Ks. Hurkadli et al., ANTIFERTILITY EFFECTS IN FEMALE RATS IMMUNIZED WITH HUMAN SEMINAL PLASMA INHIBIN, Contraception, 47(5), 1993, pp. 491-498
Citations number
22
Categorie Soggetti
Obsetric & Gynecology
Journal title
Contraception → ACNP
ISSN journal
00107824
Volume
47
Issue
5
Year of publication
1993
Pages
491 - 498
Database
ISI
SICI code
0010-7824(1993)47:5<491:AEIFRI>2.0.ZU;2-N
Abstract
Adult female rats were actively immunized with sperm-coating protein ( 10.4 KDa) human seminal plasma inhibin (HSPI). Following 8 weeks of im munization at 2.5 ug and 5 ug doses of HSPI with Freund's complete adj uvant, antifertility effects were observed in 63% (5/8) and 88% (7/8) of animals, respectively. Estrous cycle was not affected in experiment al group. Thus, the present study suggests the potential use of HSPI f or immunocontraception in females.