NEUROMUSCULAR PATHOLOGY IN THE PARANEOPLASTIC PHENOMENON ASSOCIATED WITH CERVIX CARCINOMA

A quadriceps femoris muscle biopsy from a 65 year-old female with a no n-metastatic carcinoma of cervix was studied by light and transmission electron microscopy. Different degrees of muscle fibre atrophy were o bserved and end-plates and motor nerves presented varied alterations. Intramuscular capillaries were also abnormal. A mononuclear cell infil tration was represented by lymphocytes, macrophages and mast cells. Th is study suggests a dual, neural and vascular, origin for remote cance r effects on skeletal muscle.