ALPHA-TRIFLUOROMETHYL SUBSTITUTED ALPHA-AMINO-ACIDS AND ALPHA-HYDROXYACIDS WITH ORGANOMETALLIC MOIETIES IN THE SIDE-CHAIN

Authors
SEWALD N GAA K BURGER K
Citation
N. Sewald et al., ALPHA-TRIFLUOROMETHYL SUBSTITUTED ALPHA-AMINO-ACIDS AND ALPHA-HYDROXYACIDS WITH ORGANOMETALLIC MOIETIES IN THE SIDE-CHAIN, Heteroatom chemistry, 4(2-3), 1993, pp. 253-258
Citations number
17
Categorie Soggetti
Chemistry
Journal title
Heteroatom chemistry → ACNP
ISSN journal
10427163
Volume
4
Issue
2-3
Year of publication
1993
Pages
253 - 258
Database
ISI
SICI code
1042-7163(1993)4:2-3<253:ASAAA>2.0.ZU;2-7
Abstract
Several strategies for the synthesis of alpha-trifluoromethyl substitu ted alpha-aminoacids and alpha-hydroxyacids with organometallic moieti es in the side chain are described. The preparative potential of organ ometallic substituents (organosilicon, organotin, and organocobalt moi eties) offers a convenient methodology for the synthesis of highly fun ctionalized alpha-aminoacid and alpha-hydroxyacid derivatives.