D-ALPHA-TOCOPHEROL INHIBITS LOW-DENSITY-LIPOPROTEIN INDUCED PROLIFERATION AND PROTEIN-KINASE-C ACTIVITY IN VASCULAR SMOOTH-MUSCLE CELLS

Authors
OZER NK PALOZZA P BOSCOBOINIK D AZZI A
Citation
Nk. Ozer et al., D-ALPHA-TOCOPHEROL INHIBITS LOW-DENSITY-LIPOPROTEIN INDUCED PROLIFERATION AND PROTEIN-KINASE-C ACTIVITY IN VASCULAR SMOOTH-MUSCLE CELLS, FEBS letters, 322(3), 1993, pp. 307-310
Citations number
19
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
322
Issue
3
Year of publication
1993
Pages
307 - 310
Database
ISI
SICI code
0014-5793(1993)322:3<307:DILIP>2.0.ZU;2-C
Abstract
Native and malondialdehyde modified low density lipoproteins have been shown to stimulate smooth muscle cell proliferation (A7r5) in vitro. The stimulation is associated with an increase of protein kinase C act ivity. d-alpha-Tocopherol, at physiological concentrations, has been f ound to inhibit both protein kinase C activity and cell proliferation.