ANTITHROMBOTIC EFFECT OF AN ANTI-GLYCOPROTEIN-IIB IIIA ANTIBODY IN PRIMATE LETHAL THROMBOSIS/

We investigated the antithrombotic effect of anti-glycoprotein (GP) II b/IIIa antibody in a primate model of lethal thrombosis. Eight monkeys were injected intravenously with an anti-CD9 antibody (MALL13). They died within 5 min and displayed severe thrombocytopenia. Histological examination showed multiple platelet thrombi in the pulmonary microvas culature, but no thrombi in the liver, kidneys, or spleen. In contrast ,monkeys pretreated with an anti-GPIIb/IIIa antibody (NNKY1-32) at 30 min before MALL13 administration did not die, and the thrombocytopenia in these animals did not develop as rapidly or become as severe. Thes e results suggest that the anti-CD9 antibody caused lethal pulmonary t hrombosis in vivo, and that pretreatment with the anti-GPIIb/IIIa anti body was able to prevent this thrombosis.