EFFECT OF METHYLENE-BLUE ON THE VESICOURETHRAL FUNCTION IN THE RATS

The bladder and urethral activities during the rhythmic bladder contra ctions were evaluated before and after the intraarterial administratio n of methlene blue, which prevents the activation of soluble guanylate cyclase. The methlene blue produced an increase in the bladder activi ty and a decrease in the urethral smooth muscle relaxant response indu ced with bladder contraction. The L-arginine/nitric oxide pathway seem s to modulate the vesicourethral function.