A case of successful pregnancy after BMT in a 24-year-old woman with A
LL, conditioned with CY, L-asparaginase, methylprednisolone and total
body irradiation (TBI) is reported. A second case of two spontaneously
aborted pregnancies in a woman transplanted for ALL at the age of 29
years using CY and TBI conditioning and a third case, this time a succ
essful pregnancy in a woman transplanted for AML at age 27 years using
CY and TBI conditioning are also described. There are now 6 successfu
l live births after TBI reports of, versus 16 following regimens in wh
ich no TBI is used. This is the first report of a successful pregnancy
reported in a female transplanted when older than 25 years using any
TBI-containing regimen.