Mj. Hubbard et P. Cohen, ON TARGET WITH A NEW MECHANISM FOR THE REGULATION OF PROTEIN-PHOSPHORYLATION, Trends in biochemical sciences, 18(5), 1993, pp. 172-177
There is overwhelming evidence that the reversible phosphorylation of
proteins regulates most aspects of cell life. However, the broad speci
ficities displayed by many protein phosphatases and kinases in vitro d
ictates that their activities be strictly regulated in vivo. Recent ev
idence indicates that a novel class of proteins, known as targetting s
ubunits, specifies the location, catalytic and regulatory properties o
f protein phosphatases and kinases, and thereby plays a key role in en
suring the fidelity of protein phosphorylation.