PLASMA NERVE GROWTH-FACTOR ACCESS TO THE POSTNATAL CENTRAL-NERVOUS-SYSTEM

Citation
Rh. Fabian et Ce. Hulsebosch, PLASMA NERVE GROWTH-FACTOR ACCESS TO THE POSTNATAL CENTRAL-NERVOUS-SYSTEM, Brain research, 611(1), 1993, pp. 46-52
Citations number
50
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
00068993
Volume
611
Issue
1
Year of publication
1993
Pages
46 - 52
Database
ISI
SICI code
0006-8993(1993)611:1<46:PNGATT>2.0.ZU;2-5
Abstract
The accessibility of macromolecules to the postnatal mammalian central nervous system is a subject of controversy and importance. One of the biologically important macromolecules in neural development, nerve gr owth factor (NGF), is thought to be unable to cross the blood-brain ba rrier in postnatal mammals. In this study, I-125 labeled 7S NGF was sy stemically administered to postnatal rats and was found to accumulate in the brain in significant levels. In addition, brains from saline pe rfused rats contained intact 7S NGF as determined by gel autoradiograp hy. Radiolabeled NGF was found to be localized to specific areas corre sponding to p75 NGF receptor distribution in the hippocampus and corte x by autoradiography. Circulating plasma NGF has access to the develop ing postnatal neuraxis where it may exert a humoral trophic function.