DETECTION OF IGE ANTIBODIES SPECIFIC FOR 1-PHENYL-2,3-DIMETHYL-3-PYRAZOLINE-5-ONE BY RAST - A SEROLOGICAL DIAGNOSTIC METHOD FOR SENSITIVITYTO PYRAZOLINE DRUGS

Certain adverse reactions to pyrazoline drugs resemble IgE-mediated hy persensitivity. However, convincing evidence of antigen-antibody inter actions is not fully demonstrated. in this study, IgE antibodies speci fic for 1-phenyl-2,3-dimethyl-3-pyrazoline-5-one have been found in 17 out of 19 serum samples from individuals sensitive to pyrazoline drug s with 4-aminoantipyrine discs by Radio Allergo Sorbent Test (RAST). i n contrast, we have not found any positive results from 10 normal dono rs without sensitivity to pyrazoline drugs after ingestion of metamizo l 500 mg/day for 14 days. Therefore, our results provide further evide nce in favor of an IgE-dependent mechanism in patients suffering from sensitivity to pyrazoline drugs. The determination of specific IgE ant ibodies could be used as a serodiagnostics method.