The ice cube test performed in 24 children (6 cold urticaria, 6 health
y, 6 allergic and 6 chronic urticaria) showed that a 3 and 5-minute ic
e cube test was the appropriate time for the diagnosis of cold urticar
ia without false positive results. If the test was prolonged to 10 and
20 minutes, 17% and 33% respectively showed false positive results in
chronic urticaria other than cold urticaria patients. After four week
s of cyproheptadine therapy, the ice cube test showed only 17% positiv
e al 3 minutes and 33% at 5 minutes. When the ice cube test was perfor
med for 10 and 20 minutes, 67% showed positive results. In conclusion,
the ice cube test should be performed for 3 to 5 minutes to diagnose
cold urticaria in children. The time should be increased to 10 or 20 m
inutes if the test shows negative results at 3 to 5 minutes after anti
histamine therapy.