INTERACTION OF RESPIRATORY SYNCYTIAL VIRUS WITH HUMAN CORD BLOOD MONONUCLEAR-CELLS

Authors
KOSITANONT U VUDDHAKUL V KOSITANONT C THONG YH
Citation
U. Kositanont et al., INTERACTION OF RESPIRATORY SYNCYTIAL VIRUS WITH HUMAN CORD BLOOD MONONUCLEAR-CELLS, Asian Pacific Journal of Allergy and Immunology, 10(2), 1992, pp. 135-139
Citations number
NO
Categorie Soggetti
Allergy,Immunology
Journal title
Asian Pacific Journal of Allergy and Immunology → ACNP
ISSN journal
0125877X
Volume
10
Issue
2
Year of publication
1992
Pages
135 - 139
Database
ISI
SICI code
0125-877X(1992)10:2<135:IORSVW>2.0.ZU;2-D
Abstract
This study on the interaction between respiratory syncytial virus (RSV ) and human cord blood mononuclear cells shows that RSV replication ca n occur in neonatal macrophages. Although neonatal lymphocytes were no t supportive of RSV replication, exposure to RSV resulted in significa nt inhibition of mitogen-induced transformation. Both adult and neonat al NK cell cytotoxicity were unaffected by exposure to RSV. These resu lts suggest that RSV has preferential effects on human cord blood mono nuclear cell subpopulations.