LIPASE-CATALYZED AMINOLYSIS OF ETHYL PROPIOLATE AND ACRYLIC ESTERS - SYNTHESIS OF CHIRAL ACRYLAMIDES

Authors
PUERTAS S BRIEVA R REBOLLEDO F GOTOR V
Citation
S. Puertas et al., LIPASE-CATALYZED AMINOLYSIS OF ETHYL PROPIOLATE AND ACRYLIC ESTERS - SYNTHESIS OF CHIRAL ACRYLAMIDES, Tetrahedron, 49(19), 1993, pp. 4007-4014
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
49
Issue
19
Year of publication
1993
Pages
4007 - 4014
Database
ISI
SICI code
0040-4020(1993)49:19<4007:LAOEPA>2.0.ZU;2-E
Abstract
Candida cylindracea lipase is a useful catalyst for the preparation of propiolamides, Candida antarctica lipase efficiently catalyzes the am inolysis of different acrylic esters and aliphatic amines; if racemic amines are used, the corresponding optically active acrylic amide is o btained in moderate-high enantiomeric excess.