OBJECTIVE: To contrast scientific facts with suggested manufacturers'
claims regarding food supplements (natural products) marketed for enha
nced athletic prowess. DATA SOURCES: A MEDLINE search was performed to
obtain documentation supporting the claims of natural-product manufac
turers. In addition, several references pertaining to pharmacognosy, n
atural products, herbs, pharmacy practice, and sports medicine were re
viewed. Claims were obtained from promotional advertisements in bodybu
ilding magazines, product labels, and fact sheets for sales representa
tives in nutrition and health-food stores. DATA EXTRACTION: We reviewe
d all of the clinical trials, published between 1966 and 1992, relativ
e to the manufacturers' claims regarding these products. DATA SYNTHESI
S: Pertinent human and/or animal studies supporting each natural produ
ct were compared with the manufacturers' claims. CONCLUSIONS: We found
that there was no published scientific evidence to support the promot
ional claims for a large proportion of the products (8/19,42 percent).
Only 4 of 19 products (21 percent) were associated with any documente
d human clinical trials supporting their promotional claims. Six of 19
agents (32 percent) had some scientific documentation to support thei
r promotional claims; however, these products were judged to be market
ed in a misleading manner.