F. Cassani et al., ABDOMINAL LYMPHADENOPATHY DETECTED BY ULTRASONOGRAPHY IN HIV-1 INFECTION - PREVALENCE AND SIGNIFICANCE, Scandinavian journal of infectious diseases, 25(2), 1993, pp. 221-225
By using abdominal ultrasonography (UlS), deep nodes were detected in
41 of 85 (48%) HIV-1 positive subjects, most of them heroin addicts, b
ut in none of 85 healthy HIV-negative controls. Computerized tomograph
y, performed in 10 cases of lymphadenopathy, invariably confirmed the
UIS findings. Prevalence [asymptomatic carriers: 8/15 (53%); PGL patie
nts: 8/18 (44%); ARC: 13/27 (48%); AIDS: 12/25 (48%)], number, size, a
nd site of deep nodes were comparable among the different CDC groups.
No correlation was found between abdominal and superficial lymphadenop
athy. Median serum concentrations of gammaglobulins (g/dl) and IgG (mg
/dl) were higher in patients with than without deep nodes (2.25 vs 1.8
7 and 2540 vs 1900, respectively) (p<0.01) as well as in cases with th
an without superficial nodes (2.15 vs 1.80 and 2340 vs 1941, respectiv
ely) (p<0.05). Abdominal lymphadenopathy occurred during all stages of
HIV infection even in asymptomatic carriers: this should be considere
d in the differential diagnosis of UIS-detected deep nodes. Enlargemen
t of either deep or superficial nodes seems to reflect a state of poly
clonal B cell activation.