This prospective study was carried out on 200 patients with clinically
, ultrasonographically and serologically confirmed amoebic liver absce
ss. The role of ultrasound-guided needle aspiration in addition to med
ications was evaluated compared to drug treatment alone. Both the grou
ps were monitored clinically and sonographically for up to 6 months af
ter diagnosis. The initial response (after 15 days) was better in the
aspirated group (P < 0.05) but resolution of abscess after 6 months we
re similar. There was a more rapid clinical response in the aspirated
group, particularly in those with larger (> 6 cm) abscesses and there
were no complications. Percutaneous ultrasound-guided needle aspiratio
n is a safe diagnostic and therapeutic approach which enhances clinica
l recovery, accelerates resolution, especially in large abscesses, and
prevents complications.