POLYURETHANE SURFACE MODIFICATION BY GRAFT-POLYMERIZATION OF ACRYLAMIDE FOR REDUCED PROTEIN ADSORPTION AND PLATELET-ADHESION

Authors
FUJIMOTO K TADOKORO H UEDA Y IKADA Y
Citation
K. Fujimoto et al., POLYURETHANE SURFACE MODIFICATION BY GRAFT-POLYMERIZATION OF ACRYLAMIDE FOR REDUCED PROTEIN ADSORPTION AND PLATELET-ADHESION, Biomaterials, 14(6), 1993, pp. 442-448
Citations number
15
Categorie Soggetti
Engineering, Biomedical","Material Science
Journal title
Biomaterials → ACNP
ISSN journal
01429612
Volume
14
Issue
6
Year of publication
1993
Pages
442 - 448
Database
ISI
SICI code
0142-9612(1993)14:6<442:PSMBGO>2.0.ZU;2-I
Abstract
Surface modification of polyurethane by glow-discharge treatment and s ubsequent graft polymerization of acrylamide was studied. The modified hydrophilic surfaces were characterized by the measurements of dynami c contact angle and zeta potentials and examined for protein adsorptio n behaviour and platelet adhesion. Data from in vitro and ex vivo expe riments indicated a reduction of protein adsorption and platelet adhes ion for the hydrophillic graft polymers, the extent of which was corre lated to polymer graft density.