NEGATIVE COOPERATIVITY MAY EXPLAIN FLAT CONCENTRATION-RESPONSE CURVESOF ATP-SENSITIVE POTASSIUM CHANNELS

Authors
HEHL S NEUMCKE B
Citation
S. Hehl et B. Neumcke, NEGATIVE COOPERATIVITY MAY EXPLAIN FLAT CONCENTRATION-RESPONSE CURVESOF ATP-SENSITIVE POTASSIUM CHANNELS, European biophysics journal, 22(1), 1993, pp. 1-4
Citations number
18
Categorie Soggetti
Biophysics
Journal title
European biophysics journal → ACNP
ISSN journal
01757571
Volume
22
Issue
1
Year of publication
1993
Pages
1 - 4
Database
ISI
SICI code
0175-7571(1993)22:1<1:NCMEFC>2.0.ZU;2-L
Abstract
Blockage of ATP-sensitive K+ channels by various drugs has been report ed to exhibit a weak concentration dependence with Hill coefficients b elow unity. This phenomenon is interpreted by a negative cooperativity between K+ channels whereby drug binding to one channel lowers the dr ug affinities of neighbouring channels. Results are presented for a di meric and a tetrameric channel model and compared with published exper imental data.