LINEAGE PROMISCUITY IN LEUKEMIA STUDIES OF T-CELL RECEPTOR AND IMMUNOGLOBULIN GENES

Authors
BERNARD D BIGNON YJ LAVENUE F PAUCHARD J DEMEOCQ F TRAVADE P PHILIPPE P LEGROS M CURE H CHASSAGNE J CHOLLET P PLAGNE R
Citation
D. Bernard et al., LINEAGE PROMISCUITY IN LEUKEMIA STUDIES OF T-CELL RECEPTOR AND IMMUNOGLOBULIN GENES, Leukemia research, 17(5), 1993, pp. 445-453
Citations number
29
Categorie Soggetti
Oncology,Hematology
Journal title
Leukemia research → ACNP
ISSN journal
01452126
Volume
17
Issue
5
Year of publication
1993
Pages
445 - 453
Database
ISI
SICI code
0145-2126(1993)17:5<445:LPILSO>2.0.ZU;2-Z
Abstract
Using appropriate DNA probes, the configurations of the T-cell recepto r beta-chain genes and immunoglobulin heavy-chain genes were studied i n patients diagnosed as having the following malignancies: 7 chronic m yeloid leukemia, 13 acute myeloblastic leukemia, 9 acute lymphocytic l eukemia and 20 chronic lymphocytic leukemia. Rearrangements not corres ponding to the immunotype were unexpectedly found in lineage neoplasia s.