BIOLOGICALLY IMPORTANT PHYSICOCHEMICAL PROPERTIES OF KOJIC ACID-DERIVATIVES

Physicochemical properties (hydrophobicity. acidity. metal complexing ability). which are expected to play a role in biological activity of kojic acid derivatives. were determined for 35 compounds. The structur e-property relationships were analysed with the aim to predict the pro perties of new derivatives and to obtain the data for formulation of q uantitative structure-time-activity relationships. Linear correlations were found between hydrophobicity expressed as decadic logarithm of t he 1-octanol/buffer partition coefficient and the sum of fragment cons tants and correction factors according to Leo and Hansch as well as be tween acidity and a set of Hammett constants of the varying substituen ts.