GLYCOSYLATION OF ACUTE-PHASE PROTEINS AND INTERLEUKINS FOLLOWING HIP-ARTHROPLASTY - INFLAMMATION PARAMETERS STUDIED IN 10 PATIENTS

We analyzed changes in glycosylation and serum concentrations of alpha 1-acid glycoprotein (AGP), antichymotrypsin (AC), interleukin-6 (IL-6) , soluble interleukin-2 receptor (sIL-2R) and C-reactive protein (CRP) following hip arthroplasty. Glycosylation of AGP and AC showed an inc reased reactivity to concanavalin A between postoperative Day 2 and Da y 5 and Day 10, respectively. Serum levels of AGP and AC increased at the earliest on Day 5. The AC levels returned to baseline by Day 10. A GP, however, exhibited increased values beyond Day 14. CRP levels were elevated at Day 2 and remained increased beyond Day 14. sIL2R showed increased values at Days 5, 10 and 14. IL-6 was the first parameter to increase, and it returned to baseline in less than 5 days.