EVIDENCE FOR AUTOSOMAL-DOMINANT TRANSMISSION IN TOURETTES-SYNDROME - UNITED-KINGDOM COHORT STUDY

Complex segregation analyses were performed on families ascertained th rough 40 unselected consecutive patients with Tourette's syndrome to e xamine the hypothesis that its transmission is consistent with genetic inheritance. Analyses were done using several diagnostic classificati ons. All results were consistent with an autosomal dominant gene with high penetrance. The penetrances ranged from 0.882 to 1.000 for males and 0.452 to 0.980 for females, depending upon the specific classifica tion scheme incorporated into the analyses.