Ma. Fisher et al., EFFICACY OF FENBENDAZOLE AND PIPERAZINE AGAINST DEVELOPING STAGES OF TOXOCARA AND TOXASCARIS IN DOGS, Veterinary record, 132(19), 1993, pp. 473-475
In a series of controlled trials involving 59 naturally infected greyh
ounds, fenbendazole at a dose rate of 50 mg/kg/day for three consecuti
ve days reduced the overall numbers of third and fourth stage Toxocara
canis by 94.0 per cent and third stage, fourth stage and immature adu
lt stages of Toxascaris leonina by 92.4 per cent. In contrast, piperaz
ine at 100 mg/kg had little or no useful effect against the larval sta
ges of T canis and T leonina and variable efficacy against immature ad
ult T leonina. Fenbendazole was also 100 per cent effective against im
mature Trichuris vulpis. In a separate controlled experiment, puppies
in three litters exposed to reinfection with T canis were treated with
fenbendazole at two weeks old and again only after their mean faecal
egg counts exceeded 200 epg. Between one and three doses were required
to suppress the output of eggs during the puppies' first 12 weeks of
life.