2 NEW EFFICIENT PREPARATIONS OF ENANTIOPURE 2,2'-DIHYDROXY-6,6'-DIMETHOXY-1,1'-BIPHENYL

Authors
DELOGU G FABBRI D
Citation
G. Delogu et D. Fabbri, 2 NEW EFFICIENT PREPARATIONS OF ENANTIOPURE 2,2'-DIHYDROXY-6,6'-DIMETHOXY-1,1'-BIPHENYL, Tetrahedron : asymmetry, 8(5), 1997, pp. 759-763
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
5
Year of publication
1997
Pages
759 - 763
Database
ISI
SICI code
0957-4166(1997)8:5<759:2NEPOE>2.0.ZU;2-M
Abstract
Two new useful methods for the preparation of diol 1 starting from ava ilable compounds are described. Separation of the two enantiomers enta ils resolution of racemic diol 1 via the corresponding diastereomeric N-methylated phosphorothioamidates. Their separation by recrystallizat ion followed by reduction afforded diol (aS)-1 and (aR)-1 in 100% and 72% ee, respectively. (C) 1997 Elsevier Science Ltd.