A NEW MULTIENZYME SYSTEM FOR A ONE-POT SYNTHESIS OF SIALYL OLIGOSACCHARIDES - COMBINED USE OF BETA-GALACTOSIDASE AND ALPHA(2,6)-SIALYLTRANSFERASE COUPLED WITH REGENERATION INSITU OF CMP-SIALIC ACID

Authors
HERRMANN GF ICHIKAWA Y WANDREY C GAETA FCA PAULSON JC WONG CH
Citation
Gf. Herrmann et al., A NEW MULTIENZYME SYSTEM FOR A ONE-POT SYNTHESIS OF SIALYL OLIGOSACCHARIDES - COMBINED USE OF BETA-GALACTOSIDASE AND ALPHA(2,6)-SIALYLTRANSFERASE COUPLED WITH REGENERATION INSITU OF CMP-SIALIC ACID, Tetrahedron letters, 34(19), 1993, pp. 3091-3094
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
19
Year of publication
1993
Pages
3091 - 3094
Database
ISI
SICI code
0040-4039(1993)34:19<3091:ANMSFA>2.0.ZU;2-8
Abstract
An irreversible one-pot enzymatic synthesis of sialyl oligosaccharides has been achieved with a beta-galactosidase-catalyzed galactosylation of an acceptor followed by a sialyltransferase-catalyzed sialylation with regeneration in situ of CMP-sialic acid.