ENZYMATIC-HYDROLYSIS OF HYDROPHILIC ESTERS BY LIPASES - CARBOXY DEBLOCKING OF PEPTIDES AND GLYCOPEPTIDES

Authors
BRAUM G BRAUN P KOWALCZYK D KUNZ H
Citation
G. Braum et al., ENZYMATIC-HYDROLYSIS OF HYDROPHILIC ESTERS BY LIPASES - CARBOXY DEBLOCKING OF PEPTIDES AND GLYCOPEPTIDES, Tetrahedron letters, 34(19), 1993, pp. 3111-3114
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
19
Year of publication
1993
Pages
3111 - 3114
Database
ISI
SICI code
0040-4039(1993)34:19<3111:EOHEBL>2.0.ZU;2-5
Abstract
The markedly hydrophilic 2-(N-morpholino)ethyl (MoEt) esters of protec ted peptides and glycopeptides are selectively and efficiently cleaved by lipases in water/acetone (10:1) at pH 7.