PALLADIUM-CATALYZED SYNTHESIS OF NEW UNSATURATED EXO-ENOL LACTONES WITH POTENTIAL BIOLOGICAL-ACTIVITY

Authors
BOUYSSI D GORE J BALME G LOUIS D WALLACH J
Citation
D. Bouyssi et al., PALLADIUM-CATALYZED SYNTHESIS OF NEW UNSATURATED EXO-ENOL LACTONES WITH POTENTIAL BIOLOGICAL-ACTIVITY, Tetrahedron letters, 34(19), 1993, pp. 3129-3130
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
19
Year of publication
1993
Pages
3129 - 3130
Database
ISI
SICI code
0040-4039(1993)34:19<3129:PSONUE>2.0.ZU;2-D
Abstract
Various allenenols lactones [5(E)-(2-allenylidene)-tetrahydro-2-furano nes] have been synthesized by reacting 4-pentynoic acid and 2-alkynyl acetate in dimethyl sulfoxide in the presence of K2CO3, Pd(OAc)2 as th e catalyst and tri(2-furyl) phosphine as the ligand. The biological ac tivity of these compounds as protease inhibitors has been proven.