FACILE ACCESS TO 2'-O-ACYL PRODRUGS OF BETA-D-ARABINOFURANOSYL)-5(E)-(2-BROMOVINYL)URACIL (BVARAU) VIA REGIOSELECTIVE ESTERASE-CATALYZED HYDROLYSIS OF 2',3',5'-TRIESTERS

Authors
BARALDI PG BAZZANINI R MANFREDINI S SIMONI D ROBINS MJ
Citation
Pg. Baraldi et al., FACILE ACCESS TO 2'-O-ACYL PRODRUGS OF BETA-D-ARABINOFURANOSYL)-5(E)-(2-BROMOVINYL)URACIL (BVARAU) VIA REGIOSELECTIVE ESTERASE-CATALYZED HYDROLYSIS OF 2',3',5'-TRIESTERS, Tetrahedron letters, 34(19), 1993, pp. 3177-3180
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
19
Year of publication
1993
Pages
3177 - 3180
Database
ISI
SICI code
0040-4039(1993)34:19<3177:FAT2PO>2.0.ZU;2-N
Abstract
Treatment of abinofuranosyl)-5-[2-(trimethylsilyl)-vinyl]uracil (3) wi th pyridinium bromide perbromide and deacetylation gave BVAraU (2). Pi g liver esterase (EC 3.1.1.1) catalyzed the regioselective hydrolysis of 1-(2,3,5-tri-O-acyl-beta-D-arabinofuranosyl)uracil derivatives to t heir 2'-O-acyl monoesters.