A MORPHOLOGICAL-STUDY OF THE EFFECTS OF LIPOSOMIZED ALBENDAZOLE ON THE MUSCLE PHASE OF TRICHINELLA-SPIRALIS IN MICE

The pathomorphological effects of daily and weekly doses of liposomize d albendazole on Trichinella spiralis larvae have been examined and co mpared during the course of muscle infections in mice. Treatment with three and six daily doses of the drug given by intraperitoneal injecti on to mice resulted in marked pathological alterations to encapsulated larvae, mainly in the walls of the capsules. There was a 5% efficacy against T. spiralis in mice given three daily doses of albendazole, an d 38% efficacy in mice given six daily doses of the drug. The same dos es of drug, when administered weekly, did not reduce the numbers of pa rasite larvae, and the application of drug at 6-weekly intervals resul ted in a 5% reduction in numbers.